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In episode two of The Most Unknown, Motherboard travels to Italy's Gran Sasso National Laboratory with physicist Davide D'Angelo and geomicrobiologist Jennifer Macalady for an early look at SABRE, a new dark matter experiment.

In episode one of The Most Unknown, microbiologist Jennifer Macalady, along with a team of divers, spelunk through Italy’s water-rich Frasassi Caves to search for mysterious microbes that could hold clues to the origins of life on Earth.